|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We therefore used PCR to amplify and sequence exon 3 of beta-catenin from 202 sporadic colorectal tumors.
|
10197610 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We also provided evidence for an association between colorectal tumor risk and polymorphisms in laminin gamma 1 (this is the second gene in the laminin family to be associated with colorectal cancers), cyclin D2 (which encodes for cyclin D2), and T-box 3 (which encodes a T-box transcription factor and is a target of Wnt signaling to β-catenin).
|
23266556 |
2013 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.
|
22108803 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Thus, through protein-protein interaction, EDD stabilizes APC and up-regulates APC's function to inhibit beta-catenin, suggesting that EDD could act as a colorectal tumor suppressor.
|
18076571 |
2007 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Thus, by far the most common mutations in colorectal tumors, found in the Wnt-signaling pathway and leading to the stabilizing of beta-catenin, might influence invasion by altering adhesive properties and EMT of tumor cells.
|
16091738 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, β-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, β-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.
|
27254743 |
2017 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
These results suggest that although there may be a number of mechanisms responsible for changes in beta-catenin expression in colorectal tumors, dysfunction of APC may be the major cause of this phenomenon.
|
11956815 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Therefore, beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.
|
14973118 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The prevalence of APC truncation mutants in colorectal tumors and the ability of these alleles to act dominantly to inhibit the mitotic spindle place chromosome instability at the earliest stage of colorectal cancer progression (i.e., prior to deregulation of beta-catenin).
|
19928352 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The observation that TNFRSF19 is a β-catenin target gene and TNFRSF19 receptor molecules activate NF-κB signaling shows that β-catenin regulates NF-κB activity via TNFRSF19, suggesting that TNFRSF19 may contribute to the development of colorectal tumors with deregulated β-catenin activity.
|
24623448 |
2014 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
The level of Dickkopf-4 was positively correlated with fibroblast growth factor-20 (r(s) = 0.61, P = 0.00017), a representative beta-catenin transcriptional target gene, and with the degree of nuclear accumulation of beta-catenin in colorectal tumors.
|
19659606 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
LHGDN |
The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis.
|
11920497 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The β-catenin-TCF transcription complex activates both the physiological expression of Wnt target genes in the normal intestinal epithelium and their aberrantly increased expression in colorectal tumors.
|
28708826 |
2017 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
TCF-4 and beta-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors.
|
12036905 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Some colorectal tumors with wild-type adenomatous polyposis coli gene have activating mutations in beta-catenin (encoded by CTNNB1) that result in decreased phosphorylation by GSK-3beta and increased signaling through the Tcf/Lef transcription factors.
|
10416591 |
1999 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.
|
25280562 |
2014 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Relation of E-cadherin and beta-catenin expression to pit pattern in colorectal cancer.
|
15289833 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells.
|
15888491 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin.
|
12907644 |
2003 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Prognostic significance of beta-catenin in colorectal cancer with liver metastasis.
|
17168211 |
2006 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer.
|
14977843 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Previous studies have revealed that β‑catenin is associated with TRAIL resistance in melanoma and colorectal tumors.
|
30132512 |
2018 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Positive KL-6 mucin expression combined with decreased membranous beta-catenin expression indicates worse prognosis in colorectal carcinoma.
|
18949395 |
2008 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression.
|
16124054 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
|
18951899 |
2009 |